What is the meaning of indole compounds?
Definition of indole : a crystalline alkaloid compound C8H7N that is a decomposition product of proteins containing tryptophan, that can be made synthetically, and that is used in perfumes also : a derivative of indole.
What is an example of indole alkaloids?
Two plants that contain indole alkaloids are Passiflora incarnata L. (passion flower) and Mitragyna speciosa (Korth.) Havil (kratom), while the other two plants that did not show the presence of indole alkaloids are Piper methysticum G. Forst (kava) and Valeriana officinalis L., deserve special attention.
Is indole a chemical compound?
indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.
Where are indoles found?
Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas.
What drugs contain indole?
Most drugs on the market contain the indole substructure. These include indomethacin, ergotamine, frovatriptan, ondansetron, and tadalafil.
What are indoles used for?
Indoles constitute extensively explored heterocyclic ring systems with wide range of applications in pathophysiological conditions that is, cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, etc.
What is the function of indole for bacteria?
Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation.
What bacteria can produce indole?
many pathogenic bacteria such as Bacillus alvei, pathogenic E. coli, several Shigella strains, Enterococcus faecalis, and V. cholerae, can produce indole.
What is indole in the gut?
Indole is the main metabolite produced by gut bacteria from tryptophan, through the action of the enzyme tryptophanase. While indole is a major intercellular signal within the gut microbial ecosystem (Lee and Lee, 2010), it also interacts with the gut epithelium.
What is the purpose of indole?
Indole tests may be used as an aid in the identification and differentiation of gram-positive and gram-negative organisms. Additional biochemical testing using pure cultures is recommended for complete identification. The tube test is a more sensitive method of detecting indole than the spot test.
Which one of the following drug contains indole?
How is indole produced in body?
Which drugs are indole derivatives?
Indole Derivatives
| Drug | Drug Description |
|---|---|
| Ziprasidone | An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. |
| Molindone | An antipsychotic used to treat schizophrenia. |
| Sertindole | An atypical antipsychotic indicated in the treatment of schizophrenia. |