What does SAIZEN treat?
SAIZEN is used to treat: Growth failure in children who have a deficiency of natural human growth hormone. Growth failure in girls who have a genetic condition called gonadal dysgenesis, often referred to as Turner Syndrome, which may cause short stature.
Who makes SAIZEN?
Manufactured by Merck Serono, Saizen is produced by recombinant DNA technology from a mammalian cell line (mouse C127) that was modified by the addition of the human GH gene, resulting in an identical 191-amino acid sequence and structure.
Is SAIZEN a growth hormone?
SAIZEN is a human growth hormone produced by recombinant DNA technology. SAIZEN has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone.
What is SAIZEN used for in IVF?
Saizen (somatropin [rDNA origin]) For Injection is a human growth hormone used to treat growth failure due to growth hormone deficiency.
Does Saizen need to be refrigerated?
Saizen® 8.8 mg click. easy® cartridges reconstituted with the diluent containing 0.3% (w/v) metacresol in WFI should be stored under refrigeration (2°-8°C/36°-46°F) for up to 21 days.
How much is Saizen?
Growth hormone helps children grow taller and helps adults and children grow muscle. It is used to treat many conditions of low growth hormone levels, growth failure, and short stature. The lowest GoodRx price for the most common version of Saizen is around $715.44, 23% off the average retail price of $935.47.
Where is Saizen made?
Saizen® is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone gene. Saizen®, with the correct three-dimensional configuration, is secreted directly through the cell membrane into the cell-culture medium for collection and purification.
Can you inject hGH intramuscular?
In the treatment of growth hormone deficiency, human growth hormone (hGH) injections are given intramuscularly (IM) since subcutaneous (SC) injections are considered to be immunogenic.
What are side effects of HGH?
HGH treatment might cause a number of side effects for healthy adults, including:
- Carpal tunnel syndrome.
- Increased insulin resistance.
- Type 2 diabetes.
- Swelling in the arms and legs (edema)
- Joint and muscle pain.
- For men, enlargement of breast tissue (gynecomastia)
- Increased risk of certain cancers.
How much HGH can you inject in a day?
Adults weighing 99 to 121 pounds (45 to 55 kg)—5 mg injected under the skin once a day at bedtime. Adults weighing 77 to 98 pounds (35 to 44 kg)—4 mg injected under the skin once a day at bedtime. Adults weighing less than 77 pounds (35 kg)—Dose is based on body weight and must be determined by your doctor.
Is HGH good for sperm?
Growth hormone improves semen volume, sperm count and motility in men with idiopathic normogonadotropic infertility.
What is Saizen?
Saizen is a form of human growth hormone important for the growth of bones and muscles. Saizen is used to treat growth failure in children and adults who lack natural growth hormone.
What are the side effects of Saizen?
Saizen side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Serious breathing problems may occur in patients with Prader-Willi syndrome who use Saizen.
What is the molecular weight of Saizen?
Saizen has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone. Saizen is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone gene.
Is Saizen safe to use during pregnancy?
Reproduction studies have been performed in rats and rabbits at doses up to 31 and 62 times, respectively, the human (child) weekly dose based on body surface area. The results have revealed no evidence of impaired fertility or harm to the fetus due to SAIZEN. There are, however, no adequate and well controlled studies in pregnant women.
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